本书是双语教材,总结多年教学中沉淀的经验,按照医学各专业的特点,将生物化学划分为生物大分子的结构与功能、物质代谢、基因表达和专题篇4个部分,努力构建系统化课程,从学生兴趣、认知规律和探究方便出发合理设计教材的结构,注意联系实际,适度扩大学生的知识面和应用能力,突出教材中知识结构的科学化。并以鲜活灵动的色彩、图文并茂的版面、熟悉的例子吸引刚入门的医学生,让学生感受课程学习的趣味性和挑战性,将是一系统性强、可读性强、深受学生喜爱的教材。

PART Ⅰ : STRUCTURE AND FUNCTION OF BIOMACROMOLECULE
Chapter 1 Structure and Function of Protein
SECTION 1 THE COMPOSITION OF PROTEIN
1.1 Amino acid
1.2 Peptide
1.3 Some small polypeptides have biological activity
SECTION 2 MOLECULAR STRUCTURE OF PROTEINS
2.1 Primary structure
2.2 Secondary structure
2.3 Tertiary structure
2.4 Major noncovalent bond
2.5 Quaternary structure
SECTION 3 RELATION BETWEEN STRUCTURE AND FUNCTION OF PROTEINS
3.1 Primary structure and potential function of protein
3.2 Spatial structure shows the function of protein
SECTION 4 CHEMICAL AND PHYSICAL PROPERTIES OF PROTEINS
4.1 Ultraviolet absorption spectrum of protein
4.2 Isoelectric point (pI)
4.3 Denaturation of protein
SECTION 5 ISOLATION, PURIFICATION AND SEQUENCING OF PROTEINS
5.1 Dialysis and ultrafiltration
5.2 Precipitation with acetone, salting precipitation and immunoprecipitation
5.3 Chromatographic separations
5.4 Electrophoresis
5.5 Ultracentrifugation
SUMMARY
Chapter 2 Chemistry of Nucleic Acids
SECTION 1 MOLECULAR COMPOSITION OF NUCLEIC ACIDS
1.1 Basic components
1.2 Nucleosides
1.3 Mononucleotides
SECTION 2 MOLECULAR STRUCTURES OF DNA
2.1 Primary structure of nucleic acid
2.2 Chargaff's rules
2.3 Secondary structure of DNA
SECTION 3 PHYSICO-CHEMICAL PROPERTIES OF NUCLEIC ACIDS
3.1 Viscosity
3.2 Ultraviolet absorption
3.3 Denaturation and renaturation of DNA
3.4 Hydrolysis of acid or alkali
SECTION 4 STRUCTURES OF RNA
4.1 Messenger RNA
4.2 Transfer RNA
4.3 Ribosomal RNA
SUMMARY
Chapter 3 Enzymes
SECTION 1 THE MOLECULAR COMPOSITION AND FUNCTION OF ENZYMES
1.1 The molecular composition of enzymes
1.2 The active center of enzymes
1.3 Many enzymes require cofactors
SECTION 2 PROPERTIES AND MECHANISM OF ENZYME CATALYSIS
2.1 Remarkable properties of enzymes
2.2 Mechanism of enzyme catalysis
SECTION 3 THE KINETICS OF ENZYME CATALYSIS
3.1 Catalysis occurs at the active site
3.2 Multiple factors affect the rates of enzyme-catalyzed reactions
3.3 Initial rate is proportionate to enzyme concentration
3.4 Substrate concentration affects reaction rate
3.5 The Michaelis-Menten equations model the effects of substrate concentration
3.6 Kinetic analysis distinguishes competitive from noncompetitive inhibition
SECTION 4 ZYMOGENS AND ISOZYMES
4.1 Zymogens and zymogen activation
4.2 Isozymes are physically distinct forms of the same catalytic activity
……
PART Ⅱ : METABOLISM
PART Ⅲ : GENE EXPRESSING
PART Ⅳ : SPECIAL TOPICS